BPA MAY BE LINKED TO INFERTILITY IN WOMEN

 

BPA MAY BE LINKED TO INFERTILITY IN WOMEN


A study from USA’s Brigham and Women’s Hospital (BWH) recently analyzed the effects of Bisphenol-A (BPA) on human eggs, and it may reveal why some couples are unable to conceive. The study, published online in the Journal Human Reproduction, is the first of its kind to show the direct effects of BPA on egg maturation in humans. BPA is a chemical used to make certain plastics and resins, and it can be found in some water bottles, food cans, bottle tops or water supply lines. The experiment was led by Dr. Catherine Racowsky, director of the Assisted Reproductive Technologies Laboratory at BWH.

She and her team conducted a randomized trial using 352 discarded eggs from 121 patients, who were undergoing in-vitro fertilization (IVF) at the hospital from 2011 to 2012. Subjects’ eggs were exposed to varying levels of BPA in the laboratory, but an egg from each patient was held aside and not exposed to BPA to serve as the control.
After being exposed to BPA, researchers examined the eggs and found the following results:

• Percentage of eggs that matured decreased
• Proportion that degenerated fell
• Percentage of eggs that underwent spontaneous activation increased

Researchers also noticed with eggs that did mature, they tended not to have bipolar spindles and aligned chromosomes, as unaffected eggs do.

The researchers note that the prevalence of BPA in our society is such that the general population is exposed to it on a regular basis. They also say that BPA has been detected in human follicular fluid.

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